Active Targeted Nanoformulations via Folate Receptors: State of the Art and Future Perspectives

Martín-Sabroso, Cristina and Torres-Suárez, Ana Isabel and Alonso-González, Mario and Fernández-Carballido, Ana and Fraguas-Sánchez, Ana Isabel (2021) Active Targeted Nanoformulations via Folate Receptors: State of the Art and Future Perspectives. Pharmaceutics, 14 (1). p. 14. ISSN 1999-4923

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Abstract

In normal tissues, the expression of folate receptors is low and limited to cells that are important for embryonic development or for folate reabsorption. However, in several pathological conditions some cells, such as cancer cells and activated macrophages, overexpress folate receptors (FRs). This overexpression makes them a potential therapeutic target in the treatment of cancer and inflammatory diseases to obtain a selective delivery of drugs at altered cells level, and thus to improve the therapeutic efficacy and decrease the systemic toxicity of the pharmacological treatments. Two strategies have been used to achieve this folate receptor targeting: (i) the use of ligands with high affinity to FRs (e.g., folic acid or anti-FRs monoclonal antibodies) linked to the therapeutic agents or (ii) the use of nanocarriers whose surface is decorated with these ligands and in which the drug is encapsulated. This manuscript analyzes the use of FRs as a target to develop new therapeutic tools in the treatment of cancer and inflammatory diseases with an emphasis on the nanoformulations that have been developed for both therapeutic and imaging purposes.

Item Type: Article
Uncontrolled Keywords: etarfolide; folic acid; mirvetuximab soravtansine; ovarian cancer; rheumatoid arthritis; targeted therapies; theranostic; vintafolide
Subjects: Institute Archives > Medical Science
Depositing User: Managing Editor
Date Deposited: 10 Nov 2022 05:16
Last Modified: 26 Aug 2023 06:23
URI: http://eprint.subtopublish.com/id/eprint/98

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