Effects of Adipose-Derived Biogenic Nanoparticle-Associated microRNA-451a on Toll-like Receptor 4-Induced Cytokines

Wang, Xinghua and Pham, Anthony and Kang, Lu and Walker, Sierra A. and Davidovich, Irina and Iannotta, Dalila and TerKonda, Sarvam P. and Shapiro, Shane and Talmon, Yeshayahu and Pham, Si and Wolfram, Joy (2021) Effects of Adipose-Derived Biogenic Nanoparticle-Associated microRNA-451a on Toll-like Receptor 4-Induced Cytokines. Pharmaceutics, 14 (1). p. 16. ISSN 1999-4923

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Abstract

Extracellular vesicles (EVs) are cell-released nanoparticles that transfer biomolecular content between cells. Among EV-associated biomolecules, microRNAs (miRNAs/miRs) represent one of the most important modulators of signaling pathways in recipient cells. Previous studies have shown that EVs from adipose-derived mesenchymal stromal cells (MSCs) and adipose tissue modulate inflammatory pathways in macrophages. In this study, the effects of miRNAs that are abundant in adipose tissue EVs and other biogenic nanoparticles (BiNPs) were assessed in terms of altering Toll-like receptor 4 (TLR4)-induced cytokines. TLR-4 signaling in macrophages is often triggered by pathogen or damage-induced inflammation and is associated with several diseases. This study demonstrates that miR-451a, which is abundant in adipose tissue BiNPs, suppresses pro-inflammatory cytokines and increases anti-inflammatory cytokines associated with the TLR4 pathway. Therefore, miR-451a may be partially responsible for immunomodulatory effects of adipose tissue-derived BiNPs.

Item Type: Article
Uncontrolled Keywords: exosome; extracellular vesicle; microRNA; microvesicle; Toll-like receptor 4
Subjects: Institute Archives > Medical Science
Depositing User: Managing Editor
Date Deposited: 10 Nov 2022 05:16
Last Modified: 30 Dec 2023 13:08
URI: http://eprint.subtopublish.com/id/eprint/97

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