The Impact of Head Model Choice on the In Vitro Evaluation of Aerosol Drug Delivery

Gallagher, Lauren and Joyce, Mary and Murphy, Barry and Mac Giolla Eain, Marc and MacLoughlin, Ronan (2021) The Impact of Head Model Choice on the In Vitro Evaluation of Aerosol Drug Delivery. Pharmaceutics, 14 (1). p. 24. ISSN 1999-4923

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Abstract

There are variations in the values reported for aerosol drug delivery across in vitro experiments throughout the published literature, and often with the same devices or similar experimental setups. Factors contributing to this variability include, but are not limited to device type, equipment settings, drug type and quantification methods. This study assessed the impact of head model choice on aerosol drug delivery using six different adults and three different paediatric head models in combination with a facemask, mouthpiece, and high-flow nasal cannula. Under controlled test conditions, the quantity of drug collected varied depending on the choice of head model. Head models vary depending on a combination of structural design differences, facial features (size and structure), internal volume measurements and airway geometries and these variations result in the differences in aerosol delivery. Of the widely available head models used in this study, only three were seen to closely predict in vivo aerosol delivery performance in adults compared with published scintigraphy data. Further, this testing identified the limited utility of some head models under certain test conditions, for example, the range reported across head models was aerosol drug delivery of 2.62 ± 2.86% to 37.79 ± 1.55% when used with a facemask. For the first time, this study highlights the impact of head model choice on reported aerosol drug delivery within a laboratory setting and contributes to explaining the differences in values reported within the literature.

Item Type: Article
Uncontrolled Keywords: head model; aerosol drug delivery; facemask; mouthpiece; high flow nasal cannula; vibrating mesh nebuliser; adult; paediatric; inhalation
Subjects: Institute Archives > Medical Science
Depositing User: Managing Editor
Date Deposited: 11 Nov 2022 04:38
Last Modified: 07 Sep 2023 09:34
URI: http://eprint.subtopublish.com/id/eprint/89

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