Smart Lipid-Based Nanosystems for Therapeutic Immune Induction against Cancers: Perspectives and Outlooks

Fobian, Seth-Frerich and Cheng, Ziyun and ten Hagen, Timo L. M. (2021) Smart Lipid-Based Nanosystems for Therapeutic Immune Induction against Cancers: Perspectives and Outlooks. Pharmaceutics, 14 (1). p. 26. ISSN 1999-4923

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Abstract

Cancer immunotherapy, a promising and widely applied mode of oncotherapy, makes use of immune stimulants and modulators to overcome the immune dysregulation present in cancer, and leverage the host’s immune capacity to eliminate tumors. Although some success has been seen in this field, toxicity and weak immune induction remain challenges. Liposomal nanosystems, previously used as targeting agents, are increasingly functioning as immunotherapeutic vehicles, with potential for delivery of contents, immune induction, and synergistic drug packaging. These systems are tailorable, multifunctional, and smart. Liposomes may deliver various immune reagents including cytokines, specific T-cell receptors, antibody fragments, and immune checkpoint inhibitors, and also present a promising platform upon which personalized medicine approaches can be built, especially with preclinical and clinical potentials of liposomes often being frustrated by inter- and intrapatient variation. In this review, we show the potential of liposomes in cancer immunotherapy, as well as the methods for synthesis and in vivo progression thereof. Both preclinical and clinical studies are included to comprehensively illuminate prospects and challenges for future research and application.

Item Type: Article
Uncontrolled Keywords: cancer; immunotherapy; liposomal nanosystems; synthesis; immune reagents; immunoliposomes; cancer vaccine; nano-immunotherapy; clinical trials
Subjects: Institute Archives > Medical Science
Depositing User: Managing Editor
Date Deposited: 11 Nov 2022 04:38
Last Modified: 23 Aug 2023 04:20
URI: http://eprint.subtopublish.com/id/eprint/87

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