Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis

Nugroho, Johanes and Gunadi, Ruth and Canga, Yigit (2021) Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis. Case Reports in Cardiology, 2021. pp. 1-5. ISSN 2090-6404

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Abstract

Acute limb ischemia (ALI) is rarely observed in young populations. The hypercoagulable state is a notable cause of ALI other than artery disease progression and cardiac embolization. A hypercoagulable state occurs in essential thrombocytosis because of the overproduction of hematopoietic cells secondary to the mutation of the JAK2, CALR, or MPL genes. We report a rare case of a 37-year-old woman presenting with Rutherford IIA ALI in the left lower extremity. Laboratory data revealed she had a platelet count reaching up to 1.38 mil/μL, with other blood profiles being normal. A JAK2 mutation examination was later performed and proved positive. After careful management with catheter-directed thrombolysis, surgical thrombectomy, and cytoreductive therapy using hydroxyurea, the symptoms subsided and eventually restored the patient to physical activity in less than one month.

Item Type: Article
Subjects: Institute Archives > Medical Science
Depositing User: Managing Editor
Date Deposited: 12 Dec 2022 12:02
Last Modified: 29 May 2024 05:11
URI: http://eprint.subtopublish.com/id/eprint/740

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