Determination and Evaluation of Bioavailability of Vitamins from Different Multivitamin Supplements Using a Pig Model

Yang, Pan and Wang, Huakai and Li, Longxian and Zhang, Nan and Ma, Yongxi (2021) Determination and Evaluation of Bioavailability of Vitamins from Different Multivitamin Supplements Using a Pig Model. Agriculture, 11 (5). p. 418. ISSN 2077-0472

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Abstract

This study was performed to evaluate the plasma vitamin kinetic behavior following oral vitamin supplement administration in pigs, and to determine the bioavailability of vitamins. A total of 36 pigs (fitted with jugular catheters) with an average body weight of 25 ± 2.24 kg were divided into three treatment groups: (1) placebo, (2) non-microencapsulated multivitamins supplement, or (3) lipid matrix microencapsulated multivitamins supplement. The blood samples were obtained starting pre-meal until 72 h post-meal for plasma vitamin analysis. Pharmacokinetic parameters were modeled with a non-compartmental method. The AUC (Area under the curve) from the time of dosing to the time of the last observation, Cmax (Maximum observed concentration), and MRT (Mean residence time) of α-tocopherol from oral non-microencapsulated supplement were significantly lower than oral microencapsulated supplement (p < 0.01). The average relative bioavailability of vitamin A (VA) and vitamin E (VE) from microencapsulated supplement was greater than that from non-microencapsulated supplement, but relative bioavailability of vitamin K3 (VK3) and water-soluble vitamins from microencapsulated supplement was lower than non-microencapsulated supplement. The AUC and Cmax of menadione, thiamine, and riboflavin from microencapsulated supplement were significantly lower than these parameters from oral non-microencapsulated supplement. Lipid matrix microencapsulation was able to delay absorption and improved the bioavailability of VE, whereas there were limited effects of microencapsulation on vitamin D (VD), VK3, and water-soluble vitamins.

Item Type: Article
Subjects: Institute Archives > Agricultural and Food Science
Depositing User: Managing Editor
Date Deposited: 01 Dec 2022 05:07
Last Modified: 17 Jun 2024 05:45
URI: http://eprint.subtopublish.com/id/eprint/633

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