Community-Acquired Pneumonia as a Cause of Sepsis Prognostic Factors of Pneumonias for Pathomechanism of Sepsis

The present study deal with the importance of the prognostic factors of pneumonias (severity indices) as well as the fundamental issues of the pathomechanism of sepsis. The characteristic of severe sepsis is multiorgan dysfunction associated with sepsis due to the microcirculation disfunction of the individual organs, accompanied with clinical signs of decreased consciousness, oliguria, icterus, lactate acidosis, thrombocytopenia and laboratory differences. During sepsis fundamental changes go on in the balance situation of the procoagulant-anticoagulant system of the organism. Due to the expression of the tissue factor the coagulation “cascade” system is activated in the damaged and activated endothelium, and as a result, disseminated arterial thromboses develop, and the interaction between fibrine and the thrombocytes results in the development of microvascular thromboses.