Systemic Implications of Solid Malignancies in Patients with Advanced Clinical Stage Malignancies

The present study highlights about a retrospective examination of 1800 patients diagnosed with different types of cancer, focusing on paraneoplastic disorders as well as severe infections and their main localization. The disease progression in cancer patients may occur due to the local and/or systemic spread of the primary malignancy, even though, all possible active oncological treatment options were tried. The prevalance of disorders of infectious and paraneoplastic origins in 750 patients with solid malignancies of advanced clinical stage in various locations has been reviewed by the authors in the period from 2009 to 2019. Of the infections, pneumonia and acute exacerbation of COPD occurred most frequently. According to the findings, bacterial infections in cancer patients are usually linked to severe symptoms and frequently result in sepsis. The most significant paraneoplastic disparities are those related to hemastasis and disorders of the haematological system. Of the metabolic disorders, hyponatraemia was predominant and had a significant negative affect on the quality of life of the patients. Additionally, both in number and nature, several disorders were observed related to gastrointestinal diseases, renal involvement, autoimmune processes, and endocrine disorders.