Research Progress of Epigenetics in Liver Cancer

Fu, Shijian and Guo, Min (2024) Research Progress of Epigenetics in Liver Cancer. Journal of Cancer Therapy, 15 (03). pp. 71-82. ISSN 2151-1934

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Abstract

Epigenetic changes are changes in gene expression by regulating gene transcription and translation without changing the nucleotide sequence of the genome. Although the genome itself changes during the occurrence and development of most malignant tumors, recent studies have found that epigenetic changes also play an important role in the occurrence and development of tumors. Epigenetic modification mainly includes DNA methylation, histone modification and miRNA regulation. This review focuses on the role and mechanism of epigenetic modification in the occurrence, metastasis and invasion of hepatocellular carcinoma (HCC), and summarizes the latest methods for the treatment of HCC by restoring dysregulated epigenetic modification. It provides a theoretical basis for revealing the pathogenesis of liver cancer and developing new methods of diagnosis and treatment.

Item Type: Article
Subjects: Institute Archives > Multidisciplinary
Depositing User: Managing Editor
Date Deposited: 22 Mar 2024 08:08
Last Modified: 22 Mar 2024 08:08
URI: http://eprint.subtopublish.com/id/eprint/4178

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