Thermal Liquid Biopsy (TLB) Focused on Benign and Premalignant Pancreatic Cyst Diagnosis

Hermoso-Durán, Sonia and García-Rayado, Guillermo and Ceballos-Laita, Laura and Sostres, Carlos and Vega, Sonia and Millastre, Judith and Sánchez-Gracia, Oscar and Ojeda, Jorge L. and Lanas, Ángel and Velázquez-Campoy, Adrián and Abian, Olga (2020) Thermal Liquid Biopsy (TLB) Focused on Benign and Premalignant Pancreatic Cyst Diagnosis. Journal of Personalized Medicine, 11 (1). p. 25. ISSN 2075-4426

[thumbnail of jpm-11-00025-v2.pdf] Text
jpm-11-00025-v2.pdf - Published Version

Download (4MB)

Abstract

Background: Current efforts in the identification of new biomarkers are directed towards an accurate differentiation between benign and premalignant cysts. Thermal Liquid Biopsy (TLB) has been previously applied to inflammatory and tumor diseases and could offer an interesting point of view in this type of pathology. Methods: In this work, twenty patients (12 males and 8 females, average ages 62) diagnosed with a pancreatic cyst benign (10) and premalignant (10) cyst lesions were recruited, and biological samples were obtained during the endoscopic ultrasonography procedure. Results: Proteomic content of cyst liquid samples was studied and several common proteins in the different groups were identified. TLB cyst liquid profiles reflected protein content. Also, TLB serum score was able to discriminate between healthy and cysts patients (71% sensitivity and 98% specificity) and between benign and premalignant cysts (75% sensitivity and 67% specificity). Conclusions: TLB analysis of plasmatic serum sample, a quick, simple and non-invasive technique that can be easily implemented, reports valuable information on the observed pancreatic lesion. These preliminary results set the basis for a larger study to refine TLB serum score and move closer to the clinical application of TLB providing useful information to the gastroenterologist during patient diagnosis.

Item Type: Article
Subjects: Institute Archives > Medical Science
Depositing User: Managing Editor
Date Deposited: 17 Jan 2023 06:01
Last Modified: 24 Feb 2024 03:57
URI: http://eprint.subtopublish.com/id/eprint/392

Actions (login required)

View Item
View Item