PREDICTION OF BIOACTIVITY OF PHYTOCHEMICALS IN Anethum graveolens – AN in silico APPROACH

Anethum graveolens is a popular herb widely used as flavouring agent and it yields essential oil. It is rich in polyphenols which exhibit antioxidant and carminative properties. In this work, phytochemical screening is performed to establish the presence of terpenoids, flavonoids and tannins etc. In food products, lipid peroxidation is common and to prevent it synthetic antioxidants like butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) are used and they are carcinogenic in nature. So, there is an increasing demand for plant derived antioxidants. Anethum graveolens is a plant rich in antioxidants and the present study predicts the antioxidant and bioactivity of Limonene, Carvone, α- Phellandrene, Dillapiol, Geraniol and p-Cymene. Insilico studies were carried out using PASS prediction tool and the bioactive compounds were predicted with Pa> 0.7. For these compounds, the bioactivity score is calculated and their potential medicinal value is discussed using Lipinski’s rule of 5 analysis. From the study, it is observed that all the compounds have bioactivity and are potential antioxidants that may be used in health care, cosmetic and food and beverage industry.