Mono, Bi and Trihetercyclic Compounds: Synthesis, Characterization, Physicochemical, Structural and Biological Properties

The synthesis of new mono-, bi- and tri-heterocyclic carboxylic and phosphonic acid models are
attracting the interest of research teams around the world due to the broad spectrum of activity they
present. Indeed, these biomolecules constitute a class of compounds active in biochemistry,
enzymology, medicine, agrochemical industry, and pharmacology. The Professors and Researchers,
members of the Organic Chemistry Laboratory, aware of the importance of integrating the University
into its socio-economic environment and of the interest in linking their fundamental research axes to
the world of industry, have turned to themes, at the chemistry-biology interface, focused on the search
for molecules with agrochemical, pharmaceutical, and therapeutic potential. In addition to these
properties, these molecules have several reactive centers and can be involved in different reactions,
very important steps in the formation of the organic chemist. This book covers key areas of
heterocyclic chemistry. It is based on four pillars: (1) the extension of our previous work on
heterocyclic alkylation and cycloaddition reactions to the preparation of new models of heterocyclic
and phosphonic amino acids by the substitution reaction of O-tosyl group and azide derivatives by
different amino acids with heterocyclic and non-heterocyclic chains (glycine, proline, histidine,
tryptophan...); (2) the application of the synthesis strategy provided for in the first part to the synthesis
of new mono-, bi- and tri-heterocyclic carboxylic and phosphonic models; (3) the use of spectroscopic
methods (NMR 1H, 13C, 14N, 1D, 2D, IR) and analytical techniques (X-ray diffraction, mass,
elemental analysis) for the characterization of the synthesized molecules, (4) the search for an
application to the synthesized molecules.