A Mini Review on the Thyroid Function Status by Paired Test

We classified a population of 34159 paired FT4 & TSH test results by combination of their reference
ranges. This defined 9 classes with class specific hormonal ranges and the correlation between them.
Euthyroid population (24722) having normal FT4 and TSH had (14.83–14.90 pmol/ml) and (2.40–2.43
μIU/ml) of FT4 & TSH respectively.
FT4 of a case alone can identify its class because the FT4 of a class has significant mean difference
from all the rest 8 classes (sig <.002) except in 2 specific situations which can be solved by their TSH
(sig.000).
There is no strong association between FT4 and TSH in any of our class (r <.445) and so it warns not
to use TSH alone in diagnostic or follow-up settings.
We believe that immediate valuable output of our study is the target of single biochemical goal for all
thyroid cases with abnormal function. We opine that future trends of research should focus on search
of aetiology/cause(s) for individual class and the cumulative data of such studies will help us to
understand the phenomenon of shifting of functional status of cases with particular aetiology, to
simplify diagnostic and therapeutic workups and also to develop better management protocols for
common as well as rare & emerging disorders in thyroid medicine.