CFA WITHOUT BOOSTER DOSE OF ADJUVANT (IFA) IN ARTHRITOGENESIS AND THE ROLE OF NEURONAL ORGANS IN WISTAR RATS, RATTUS NORVEGICUS

Systemic rheumatic diseases of autoimmune origin are characterised by inflammation of the musculo-skeletal regions. Complex interactions between immunal, neuronal and vascular endothelial system seem to play roles in the arthritogenesis. In the present study, neuronal metabolism of CFA induced arthritic rats without booster dose revealed elevation of free sugars (pentose, hexose and ketose) and reduction of protein bound carbohydrates. The intermediary metabolites viz. lactic acid, pyruvic acid and lactate/pyruvate ratio revealed significant changes. The changes imply the development of chronic hypoxia consequent to adjuvant stress. The uric acid level increased six-fold as compared to its level in control. Its formation in brain is of importance, as uric acid is attributed as one of the factors of inflammation. The results on the activity of lactate dehydrogenase and phosphatases attributed their role in immune complex formaticn. Significant reduction in GOT and GPT activity are attributed to inflammation associated neuronal metabolic changes.