Dimethoate Induced Stress on Heart of Swiss Albino Mice and Cardio-Protective Effects of Leaf Extract of Zizyphus nummularia

As human started their life on earth they faced two major problems, one is pest and other is diseases. Many pesticides are used to destroy and repel the pest. Dimethoate is an organophosphate pesticide extensively used in horticulture. The main purpose of the research was to see the effects of dimethoate induced stress in heart of albino mice and ameliorative effects of LEZN. Study was carried out for one month schedule, where different doses of dimethoate and LEZN were administered in albino mice.

105 days aged mice were selected as experimental material and divided into five groups as G1A (control group), G2A(treated with 1/5th LD50 of dimethoate),G3A(treated with 1/5th LD50 of dimethoate and LEZN),G4A(treated with 1/10th LD50 of dimethoate) and G5A (treated with 1/5th LD50 of dimethoate and LEZN).

Introduction of Dimethoate altered the value of blood indices (MCV, MCH, MCHC), certain enzyme (LDH,ACP,ALP) and CHL. These alteration lead oxidative stress in heart of albino mice and co administration of LEZN showed remedial effects.