Investigating the Possible Cardio-Protective Effects of Telmisartan against 5-Fluorouracil- Induced Cadiotoxicity in Wister Rats

Khudhair, Alaa Radhi and Numan, Intesar T. (2021) Investigating the Possible Cardio-Protective Effects of Telmisartan against 5-Fluorouracil- Induced Cadiotoxicity in Wister Rats. In: Technological Innovation in Pharmaceutical Research Vol. 7. B P International, pp. 1-8. ISBN 978-93-91312-80-0

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Abstract

Objective: The present study was designed to investigate the protective effects of telmisartan against 5-FU induced cardiotoxicity in Wister rats.

Methods: Thirty-six Wister rats were randomly divided into six groups: I, negative control receiving normal saline (2 ml/kg) orally for 30 successive days; II, positive control receiving normal saline (2ml/kg/day) orally for 25 days, and subsequently received 5-Fluorouracil (5-FU) (20 mg in 2 ml normal saline per kg body weight) once daily by intraperitoneal injection in association with normal saline for a 5 days; III and IV, receiving telmisartan (5mg and 10mg/kg/day) respectively for 30 successive days; V and VI, receiving telmisartan (5 mg and 10 mg/kg/day) orally for 25 days, and subsequently received 5-FU (20 mg in 2ml normal saline per kg body weight) once daily by intraperitoneal injection in association with normal saline for a 5 days respectively.

Results: Prophylactic treatment of telmisartan significantly attenuates the serum cardiac troponin T, aspartate Aminotransferase (AST) and alanine.

Aminotransferase (ALT) elevation caused by 5-FU-induced cardiotoxicity.

Conclusion: results of the present finding suggest that telmisartan may be a useful modulator in mitigating 5-FU induced cardiotoxicity.

Item Type: Book Section
Subjects: Institute Archives > Medical Science
Depositing User: Managing Editor
Date Deposited: 04 Dec 2023 03:31
Last Modified: 04 Dec 2023 03:31
URI: http://eprint.subtopublish.com/id/eprint/3303

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