Khudhair, Alaa Radhi and Numan, Intesar T. (2021) Investigating the Possible Cardio-Protective Effects of Telmisartan against 5-Fluorouracil- Induced Cadiotoxicity in Wister Rats. In: Technological Innovation in Pharmaceutical Research Vol. 7. B P International, pp. 1-8. ISBN 978-93-91312-80-0
Full text not available from this repository.Abstract
Objective: The present study was designed to investigate the protective effects of telmisartan against 5-FU induced cardiotoxicity in Wister rats.
Methods: Thirty-six Wister rats were randomly divided into six groups: I, negative control receiving normal saline (2 ml/kg) orally for 30 successive days; II, positive control receiving normal saline (2ml/kg/day) orally for 25 days, and subsequently received 5-Fluorouracil (5-FU) (20 mg in 2 ml normal saline per kg body weight) once daily by intraperitoneal injection in association with normal saline for a 5 days; III and IV, receiving telmisartan (5mg and 10mg/kg/day) respectively for 30 successive days; V and VI, receiving telmisartan (5 mg and 10 mg/kg/day) orally for 25 days, and subsequently received 5-FU (20 mg in 2ml normal saline per kg body weight) once daily by intraperitoneal injection in association with normal saline for a 5 days respectively.
Results: Prophylactic treatment of telmisartan significantly attenuates the serum cardiac troponin T, aspartate Aminotransferase (AST) and alanine.
Aminotransferase (ALT) elevation caused by 5-FU-induced cardiotoxicity.
Conclusion: results of the present finding suggest that telmisartan may be a useful modulator in mitigating 5-FU induced cardiotoxicity.
Item Type: | Book Section |
---|---|
Subjects: | Institute Archives > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 04 Dec 2023 03:31 |
Last Modified: | 04 Dec 2023 03:31 |
URI: | http://eprint.subtopublish.com/id/eprint/3303 |