Establishing Transductional Relationships: Viral Vectors as an Experimental Tool in ALS (Amyotrophic Lateral Sclerosis)

This contribution describes a number of historical aspects of discoveries made in the field of research called signal transduction by analyzing the meaning of the term and its relations to phenomena. Signal transduction refers to any process by which a cell converts one kind of signal or stimulus into another. For instance, that the epigenetic defect may result in additional genetic lesions has been associated with signal transduction pathways. These processes most often involve ordered sequences of biochemical reactions inside the cell, that are carried out by enzymes, and activated by second messengers. Thus suggesting the idea of reversibility at the leading edge of a transduction cascade as the most instrumental value in unveiling the ontology of its downstream elements. The purpose of this essay is to facilitate the historical and philosophical understanding of signaling pathways ultimately designed for the development of novel therapeutic strategies to treat neurological disorders. The repertoire of signal transduction pathways offered by nitric oxide (NO) and the strong ability of viral therapies to liaise effectively with the neurodegenerative sickness progression are researched. In particular, viral therapy research in ALS (amyotrophic lateral sclerosis) as a completely dominated by theory experimentation is taken as an example.