Determining the Serum Psedocholinesterase Levels Following Diazinon Poisoning in Relation to Liver Function-Prognostic and Therapeutic Value

Background: Study of serum pseudo-cholinesterase (PChE) levels gives the knowledge of the therapeutic efficacy and severity of liver dysfunction & serves as a prognostic & therapeutic index of liver injury in individuals with Diazinon poisoning with or without alcoholism. Methods: Blood samples were collected from normal male adults as control and PChE is estimated. Blood samples were taken on the 1st day and on 5th day for pseudocholinesterase estimation, from diazinon poisoning patients with or without alcoholism,attending local hospitals. Serum PChE was estimated. Results: Serum PChE was estimated among the normal healthy male adults & taken as the normal value. Among 30 normal adults, the control value of PChE ranged between 125 and 321 mol/ml with 212 as the mean. Following the treatment with atropine, PAM(Pyridine-2-Aldoxime) and blood transfusion, blood samples were estimated on 5th day, among patients with diazinon poisoning. Their mean value was found to be 200 mol/ml. There is a tendency of rise of level of serum PChE in the non-alcoholics with diazinon poisoning. Recovery of serum PChE levels towards normal value is satisfactory. Among individuals with alcohol and diazinon poisoning, on 1st day, the serum PChE is comparatively lower. The value is 100 mol/ml. This unsatisfactory response is probably due to additional hepatotoxicity of alcohol and diazinon poisoning. Conclusions: In diazinon poisoning without alcoholism, the drugs' prognostic and therapeutic efficacy is superior to that of alcoholics. As a result, there is a possibility of requiring hepatoprotective measures.