Energy-Saving Pre-Gelatinization of Arthocarpus altilis Fruits Starch and Evaluation as Disintegrant in Oral Paracetamol Tablets

Uwah, T. O. and Effiong, D. E. and Akpabio, E. I. and Jacob, G. and Awa, I. (2021) Energy-Saving Pre-Gelatinization of Arthocarpus altilis Fruits Starch and Evaluation as Disintegrant in Oral Paracetamol Tablets. In: Current Aspects in Pharmaceutical Research and Development Vol. 6. B P International, pp. 61-77. ISBN 978-93-5547-293-9

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Abstract

Modifying natural polymers have imparted desirable properties making them suitable as pharmaceutical additives. This work was to prepare pre-gelatinized breadfruit starch using acetone to reduce drying time and energy expended. The modified starch was evaluated as a disintegrant in paracetamol oral compacts. The mode of incorporation of disintegrants has been reported to affect their performance and the quality of tablet and its release profile. Starch from unripe mature bread fruit was pre-gelatinized, precipitated with acetone to reduce drying time. Native and pre-gelatinized starches were characterized for micromeritics, compatibility studies with test drug using Fourier Transform Infra-Red (FT-IR) and water interaction properties (viscosity, swelling power and hydration capacity). Paracetamol granules formed by wet granulation were compacted incorporating starches as disintegrant intragranularly, extragranularly and combining both methods. Disintegration and dissolution studies done. Pre-gelatinization did not alter the native starch chemically and their pH were within pharmaceutical limits. The disintegration efficiency ratio (DER) for the P2 and P3 (tablet batches with pre-gelatinized starches) compared favourably with that of corn starch. Also, the dissolution kinetics of the breadfruit starches followed the Hixson Crowel’s model while that of reference corn starch was best described by the Higuchi kinetic model. Breadfruit starch is edible and the properties of its pre-gelatinized form as a disintegrant compares favourably with corn starch BP. It could be an good alternative as pharmaceutical excipient.

Item Type: Book Section
Subjects: Institute Archives > Medical Science
Depositing User: Managing Editor
Date Deposited: 16 Oct 2023 03:29
Last Modified: 16 Oct 2023 03:29
URI: http://eprint.subtopublish.com/id/eprint/3153

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