Control of Hyperlipidemia in Rats By Using Papaya and Stirred Yoghurt

Current research aims to study the effect of feeding on stirred yoghurt only, papaya only and stirred yoghurt supplemented with 20% papaya on hyperlipidemia male rats. The study was conducted on 36 male albino rats divided into two main groups, the first main group 6 rats were fed on basal diet only and contrived as control group, while the second main group 30 rats with induced hypercholesterolemia through nutrition on a diet high in cholesterol content1%, the second group were divided into five equal subgroups and fed for 2 months.one subgroup was left as a positive control group (Group 1),whereas group (2)was treated with atorvastatin (10 mg/kg) orally, while groups(3,4,5) have been fed adding stirred yoghurt only , papaya only and stirred yoghurt supplemented with 20% papaya by rate (5m1/kg b.w) orally using a stomach tube daily for 8 weeks. The results revealed that all treated rat groups(experimental groups) showed a significant decrease in TC , TG , LDL-C ,VLDL-C homocysteine, TC / HDL-C and LDL-C / HDL-C than positive control group , while HDL-c was increased , in compared with the control (+ve) group. As a result, the best values of these variables appeared in stirred yoghurt supplemented with 20% papaya , atorvastatin and papaya only in compared with the other treated groups .The results revealed that liver enzymes (AST, ALT) showed significant decrease in all treated rat groups , All treated groups showed a significant increase in SOD, GSH and CAT and showed a significant decrease in MDA compared with the control (+ve) group. Histopathological examination of the rat's hearts confirmed this amelioration in rats group that consumed stirred yoghurt supplemented with 20% papaya .
The study recommended the use of stirred yoghurt supplemented with 20% papaya in patients meals suffering from hyperlipidemia.