Dietary Rice Bran-Modified Human Gut Microbial Consortia Confers Protection against Colon Carcinogenesis Following Fecal Transfaunation

Parker, Kristopher D. and Maurya, Akhilendra K. and Ibrahim, Hend and Rao, Sangeeta and Hove, Petronella R. and Kumar, Dileep and Kant, Rama and Raina, Bupinder and Agarwal, Rajesh and Kuhn, Kristine A. and Raina, Komal and Ryan, Elizabeth P. (2021) Dietary Rice Bran-Modified Human Gut Microbial Consortia Confers Protection against Colon Carcinogenesis Following Fecal Transfaunation. Biomedicines, 9 (2). p. 144. ISSN 2227-9059

[thumbnail of biomedicines-09-00144-v2.pdf] Text
biomedicines-09-00144-v2.pdf - Published Version

Download (2MB)

Abstract

Rice bran, removed from whole grain rice for white rice milling, has demonstrated efficacy for the control and suppression of colitis and colon cancer in multiple animal models. Dietary rice bran intake was shown to modify human stool metabolites as a result of modifications to metabolism by gut microbiota. In this study, human stool microbiota from colorectal cancer (CRC) survivors that consumed rice bran daily was examined by fecal microbiota transplantation (FMT) for protection from azoxymethane and dextran sodium sulfate (AOM/DSS) induced colon carcinogenesis in germ-free mice. Mice transfaunated with rice bran-modified microbiota communities (RMC) harbored fewer neoplastic lesions in the colon and displayed distinct enrichment of Flavonifractor and Oscillibacter associated with colon health, and the depletion of Parabacteroides distasonis correlated with increased tumor burden. Two anti-cancer metabolites, myristoylcarnitine and palmitoylcarnitine were increased in the colon of RMC transplanted mice. Trimethylamine-N-oxide (TMAO) and tartarate that are implicated in CRC development were reduced in murine colon tissue after FMT with rice bran-modified human microbiota. Findings from this study show that rice bran modified gut microbiota from humans confers protection from colon carcinogenesis in mice and suggests integrated dietary-FMT intervention strategies should be tested for colorectal cancer control, treatment, and prevention.

Item Type: Article
Subjects: Institute Archives > Biological Science
Depositing User: Managing Editor
Date Deposited: 08 Mar 2023 06:59
Last Modified: 27 Feb 2024 03:58
URI: http://eprint.subtopublish.com/id/eprint/1265

Actions (login required)

View Item
View Item