Immature Platelet Fraction as a Non-Invasive Marker for Esophageal Varices

Sayed Negm, Osama El. and ALBendary, Amal Saeid and Abd-Elsalam, Sherief Mohamed and Soliman, Alyaa Marzouk (2021) Immature Platelet Fraction as a Non-Invasive Marker for Esophageal Varices. Journal of Advances in Medicine and Medical Research, 33 (3). pp. 55-64. ISSN 2456-8899

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Abstract

Background: All cirrhotic patients should be screened for oesophageal varices (OV) at the time of diagnosis. The development of a non-invasive method for the detection of OV is a vital issue in subjects with cirrhosis to decrease the need for invasive endoscopic procedures that can be costly. This work aimed to evaluate immature platelet fraction (IPF) as a non-invasive marker and predictor of OV.

Methods: This cross-sectional study was carried out on 80 cirrhotic patients with esophageal varices diagnosed by upper endoscopy. They were divided into Group (1): 40 patients with cirrhosis with esophageal varices and Group (2): 40 patients with cirrhosis and without esophageal varices. All patients were subjected to the complete history taking, physical examination, routine laboratory investigations (Complete blood count, IPF, C-reactive protein, Liver and kidney function tests, Bone marrow aspiration for some cases, Ascetic sample analysis when applicable), Pelvic-Abdominal ultrasonography, Child Pugh score assessment, Upper GIT endoscopy.

Results: There was a significant difference between the studied groups regarding IPF (p<0.001). At cutoff >12 IPF had (AUC= 0.993) with sensitivity of 97.5% and specificity of 97.5% for detection of esophageal varices. There was a significant negative correlation between IPF and platelets count (p- value < 0.001). There was a significant positive correlation between IPF and Child Pugh score (p- value <0.001). There was a highly significant positive correlation between IPF and CRP (p value <0.001). There was significant difference between the two groups as regards splenic longitudinal diameter (p<0.001). As regards platelet count, there was a significant difference between the two groups (p<0.001). It was significantly lower in Group 1.

Conclusions: IPF is elevated in cirrhotic patients with naive esophageal varices than in cirrhotic patients without varices. IPF could be used as a noninvasive, easy to measure method for detection of the presence of esophageal varices at a cutoff level of >12.

Item Type: Article
Uncontrolled Keywords: Cirrhosis; immature platelet fraction; non-invasive assessment; esophageal varices.
Subjects: Institute Archives > Medical Science
Depositing User: Managing Editor
Date Deposited: 12 Nov 2022 06:12
Last Modified: 20 Sep 2023 05:56
URI: http://eprint.subtopublish.com/id/eprint/106

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